EFTA02667398.pdf

From: jeffrey E. <jeevacation@gmail.com> Sent: Wednesday, December 7, 2016 3:39 PM To: Donald Rubin Subject: Re: Placebo effects, EB, etc. three way skype for 3. and yes 1 face to face On Wed, Dec 7,=2016 at 11:37 AM, Donald Rubin < > wrote: Differe=t ways to follow up. 1. The next time that =e're in the same town, we could talk about the statistical ideas u=derlying ways to disentangle placebo effects from biological effects of dr=gs and why that's important for FDA approvals and for prescripts i= the docs office — different answers, I think. 2. I can send some recent things on the topic of placebo respon=e, which are still not that wonderfully written. =. If interested in exploring investing in EB, I can put you in touch=with Adriaan, who lives in Amsterdam. Are any of =hese appealing? I prefer 1 to 2. I think a face to face versio= of 3 could be arranged either here or there. let=me know. On Dec 7, 2016= at 9:35 AM, jeffrey E. <jeevacation@gmail.com <mailtoleevacation@gmail.com» wrote: I'm always int=rested in unique idea =n Wed, Dec 7, 2016 at 10:12 AM Donald Rubin <dbrubin@me.com <mailto:dbrubin@=e.com> wrote: Hello Jeffrey, I'm glad that Martin has put u= in touch for a couple of reasons. First, I think we have some mutua= interests concerning the complications of doing experiments with humans, =ather than plants or animals or tires. One complication is noncompli=nce with the assigned treatment, which we briefly discussed at the dinner,=but the more interesting one is the placebo effect, which can be gigantic,=for example in "viagra" type studies, which we didn*=99t get around to discussing except indirectly in the context of the Emoti=nal Brain (EB) female viagra issue. More generally, this is relate= to FDA standards for approving drugs. A slight aside: in January I=E24040m one of three people getting honorary degrees from the Medical Fa=ulty of the University of Uppsala in Sweden, where one of the others is Ro=ert Califf, the current Commissioner of the FDA (the other is Marcia McNut=, the current President of the National Academy of Sciences), so I should =et the chance to bend his ear at various meals (a former commissioner Q=80Q under Bush II — was a partial PhD student of mine when he wa= getting his MD at Harvard and his PhD in Econ at MIT, and remains a good =riend: Mark McClellen, who is interested in this stuff and remains quite i=fluential in DC, I think). EFTA_R1_01919122 EFTA02667398  But the reason for rambling about the =DA and placebo effects is the following. This morning I just had an =xchange of emails with the CEO of EB, whom I've known and worked w=th for about three years, Adriaan Tuiten. He wrote that FDA has agre=d with EB's proposal for more trials, and the EB board of director= just approved the issuance of about 12 million Euros in stock to pay for =hese trials. Adriaan thinks that they may have enough connections no=, but would you be interested in participating? I already have some =tock, which I earned though consulting. I think EB is interesting b=t still needs more wisdom when it comes to their statistics (I've =een to FDA with them two or three times, and I think they still need help =ith some of their ideas e.g., using SNPs). If interested in tossing =ome money their way, let me know. In any case, I very much enjoyed our I=st conversations, and I look forward to seeing you again, either in Cambri=ge or in NYC, which I'll probably get to in the next couple of wee=s. Best wishes, Don cr. class="m_-1196805788815373682gmail_msg"> Donald B. Rubi= John L. Loeb Professor of St=tistics Department of Statist=cs, Harvard University 1 Oxfo=d Street Cambridge MA 02138I > On Dec 2, 2016, at 9:41 AM, jeffrey E. <jeevacation@gmail.com> wrote: great On Fri, Dec 2, 2016 at 9:40 A=, Donald Rubin <dbrubin@me.com> wrote: Great, thanks =artin. Sometime when I get to NYC, which I often do to visit Columbi= connections, I'd like to be in touch, and give Jeffery more lectu=es in statistics — I think he has some potential! Also, Martin, should we try to touch base on Monday? =he rest of the week is pretty much shot for me with visitors. 2 EFTA_R1_01919123 EFTA02667399  Best, Don =br> > On Dec 2, 2016, at 9:32 AM, Nowak, Martin A. «= href="mailto class="m_-1196805788815373682g=ail_msg" target="_blank" wrote: > Don , Jeffrey > I w=uld like to put you in direct email contact. > also cc Lesley. >m 3 EFTA_R1_01919124 EFTA02667400  plea=e note The information contained in this communication is=br class="m_- 1196805788815373682gmail_msg">confidential, may be attorney=client privileged, may consti=ute inside information, and is intended only for the use of the addressee. It is the property of JEE Unauthorized use, disclosure or copying of this communication or any part thereof is strictly=prohibited and may be unlawfu=. If you have received this c=mmunication in error, please notify us immediately by return e-mail or by e-mail to jeevacation@gmail.com <mailtcyje=vacation@gmail.com> , and destroy this communication and all copies thereof, including all attachments. copyright -all right= reserved <=r> please note<=r> The information contained in this communication is confidential,=may be attorney-client privileged, may constitute inside information, a=d is intended only for the use of the addressee. It is the property ofar>JEE Unauthorized use, disclosure or copying of this communication =r any part thereof is strictly prohibited and may be unlawful. If you h=ve received this communication in error, please notify us immediately b= return e-mail or by e-mail to jeevacation@gmail.com <mailto:jeevacation@gmail.com> , and destroy this communica=ion and all copies thereof, including all attachments. copyright -all r=ghts reserved 4 EFTA_R1_01919125 EFTA02667401