EFTA02667101.pdf

From: jeffrey E. <jeevacation@gmail.com> Sent: Wednesday, December 7, 2016 5:48 PM To: Donald Rubin Subject: Re: Placebo effects, EB, etc. i might come up again, will know tomrow. let y=u know. On Wed, Dec 7, 2016 at 1:47 PM, Donald Rubin & >= wrote: Think so. Where will you be? On Dec 7, 2016, at 12:25=PM, jeffrey E. <jeevacation@gmail.com <mailto:jeevacation@gmail.com» wrote: ar you around =n the weekend in cambridge.? =br> On Wed, Dec 7, 2016 at 1:10 PM, Donald Rubin= wrote: OK. I'll get back to you=after I make contact with Adriaan again, and my plans settle a bit. <=iv> On Dec=7, 2016, at 10:38 AM, jeffrey E. <jeevacation@gmail.com <mailto:jeevacation@gmail.c=m> wrote: =div> three way skype for 3. and yes 1face to face On Wed, D=c 7, 2016 at 11:37 AM, Donald Rubin wrote: Di=ferent ways to follow up. 1. The next time =hat we're in the same town, we could talk about the statistical id=as underlying ways to disentangle placebo effects from biological effects 4 drugs and why that's important for FDA approvals and for prescri=ts in the docs office — different answers, I think. =/div> 2. I can send some recent things on the topic of placebo r=sponse, which are still not that wonderfully written. EFTA_R1_01918720 EFTA02667101  =div>3. If interested in exploring investing in (El, I can put you in =ouch with Adriaan, who lives in Amsterdam. Are an= of these appealing? I prefer 1 to 2. I think a face to face v=rsion of 3 could be arranged either here or there. Let me know. On Dec 7,=2016, at 9:35 AM, Jeffrey E. <jeevacation@gmail.com <mailto:jeevacation@gmail.com> wrote: I'm always interested in unique idea On Wed, Dec 7, 2016 at 10:=2 AM Donald Rubin wrote: </=iv> Hello Jeffrey, I'm glad that Martin has put us in touch for a co=ple of reasons. First, I think we have some mutual interests concern=ng the complications of doing experiments with humans, rather than plants =r animals or tires. One complication is noncompliance with the assig=ed treatment, which we briefly discussed at the dinner, but the more inter=sting one is the placebo effect, which can be gigantic, for example in Q=804,viagra" type studies, which we didn't get around to d=scussing except indirectly in the context of the Emotional Brain (EB) fema=e viagra issue. More generally, this is related to FDA standards for approving drugs= A slight aside: in January I'm one of three people getting-honorary degrees from the Medical Faculty of the University of Uppsala in =weden, where one of the others is Robert Califf, the current Commissioner =f the FDA (the other is Marcia McNutt, the current President of the Nation=l Academy of Sciences), so I should get the chance to bend his ear at vari=us meals (a former commissioner — under Bush II — was a pa=tial PhD student of mine when he was getting his MD at Harvard and his PhD=in Econ at MIT, and remains a good friend: Mark McClellen, who is interest=d in this stuff and remains quite influential in DC, I think). But the reason for ra=bling about the FDA and placebo effects is the following. This morni=g I just had an exchange of emails with the CEO of EB, whom I've k=own and worked with for about three years, Adriaan Tuiten. He wrote =hat FDA has agreed with EB's proposal for more trials, and the EB =oard of directors just approved the issuance of about 12 million Euros in =lock to pay for these trials. Adriaan thinks that they may have enou=h connections now, but would you be interested in participating? I a=ready have some stock, which I earned though consulting. I think EB=is interesting but still needs more wisdom when it comes to their statisti=s (I've been to FDA with them two or three times, and I think they=still need help with some of their ideas e.g., using SNPs). If inter=sted in tossing some money their way, let me know. In any case, I very much enjoyed our las= conversations, and I look forward to seeing you again, either in Cambridg= or in NYC, which I'll probably get to in the next couple of weeks= Best wishes, Do= 2 EFTA_R1_01918721 EFTA02667102  =br> Donald B. Rubin John L. Loeb Professor of Statistics Department of Statistics, Harvard University On Dec 2, 2016, at 9:41 AM, jeffrey E. <jeevacation@gmail.com <mailto:jeevacat=on@gmail.com» w=ote: great On Fri, Dec 2, 2016 at 9:40 AM=Donald Rubin wrote: =blockquote class="gmail_quote m_-4784656824216837517m_- 66983461366104204=2m_-1196805788815373682gmail_msg" style="margin:0 0 0 .8ex;border-left:1=x #ccc solid;padding-left:lex"> Great, thanks Martin= Sometime when I get to NYC, which I often do to visit Columbia conn=ctions, I'd like to be in touch, and give Jeffery more lectures in=statistics — I think he has some potential! =br class="m_-4784656824216837517m_-6698346136610420412m_- 119680578881537=682gmail_msg"> Also, Martin, should we try to touch base on Monday?=C21> The rest of the week is pretty much shot for me with visitors. Best, Don 3 EFTA_R1_01918722 EFTA02667103  > On D=c 2, 2016, at 9:32 AM, Nowak, Martin A. <mailto: wrote: > Don , Jeffrey > I would like to put you in direct email contact. <=r>> > also cc Lesley. &g=; =br class="m_-4784656824216837517m_-6698346136610420412m_- 119680578881537=682gmail_mse> please not= The information contained in this communica=ion is 4 EFTA_R1_01918723 EFTA02667104  confidential, may be attorney-client privileged, may<=1 class="m_- 4784656824216837517m_-6698346136610420412m_-1196805788815373=82gmail_msg">constitute inside information, and is intended only for the use of the addressee. It is the property of JEE<=r class="m_-4784656824216837517m_-6698346136610420412m_- 1196805788815373=82gmail_msg">Unauthorized use, disclosure or copying of this and=may be unlawful. If you have received this communication in =rror, please notify us immediately by return e-mail or by e-=ail to jeevacation@gmail.com <mailto:jeevacation@gmail.com> , and destroy this communication =nd all copies thereof, including all attachments. copyright =all rights reserved =/div> 4>=A0 please note The information conta=ned in this communication is confidential, may be attorney-client privi=eged, may constitute inside information, and is intended only for th= use of the addressee. It is the property of TEE Unauthorized use, d=sclosure or copying of this communication or any part thereof is strict=y prohibited and may be unlawful. If you have received this communic=tion in error, please notify us immediately by return e-mail or by e-ma=l to jeevacatio=@gmail.com <mailto:jeevacation@gmail.com> , and destroy this communication and all copies thereof,<=r>including all attachments. copyright -all rights reserved Q=A0 please note 5 EFTA_R1_01918724 EFTA02667105  The information contained in this=communication is confidential, may be attorney-client privileged, mayconstitute inside information, and is intended only for the use of the=addressee. It is the property of JEE Unauthorized use, disclosure or=copying of this communication or any part thereof is strictly prohibite= and may be unlawful. If you have received this communication in err=r, please notify us immediately by return e-mail or by e-mail to jeevacation@gmail.com<=a>, and destroy this communication and all copies thereof, including=all attachments. copyright -all rights reserved p=ease note The information contained in this communication is co=fidential, may be attorney-client privileged, may constitute inside inf=rmation, and is intended only for the use of the addressee. It is the p=operty of JEE Unauthorized use, disclosure or copying of this com=unication or any part thereof is strictly prohibited and may be unlawfu=. If you have received this communication in error, please notify us im=ediately by return e-mail or by e-mail to jeevacation@gmail.com <mailto:jeevacation=gmail.com> , and destroy thi= communication and all copies thereof, including all attachments. copyr=ght -all rights reserved 6 EFTA_R1_01918725 EFTA02667106