EFTA01977947.pdf

To: MICHAEL BUCHHOLTZ[ From: Jeffrey Epstein Sent: Wed 11/14/2012 8:43:28 PM Subject: Re: I will do On Wed, Nov 14, 2012 at 3:35 PM, MICHAEL BUCHHOLTZ wrote: There are several companies doing this. I believe it is the future of personalized medicine/cancer care. Frustratingly much of the present data has not been validated by large clinical studies. I have had numerous patients use various assays and results have been more misses than hits. Despite my scepticism I certainly would be interested / fully supportive of having Warrens tumor tested and see what recommendations they come up with. Find out what they need; fresh tissue or slides/a tumor block . If you want I can also investigate further as well. Michael On Wed, Nov 14, 2012 at 2:03 PM, Jeffrey Epstein wrote: I just talked to bill gates , the company called foundation medicen sequence the gene against a data base of all medicnes, useful? or not what do you know about it or think? On Wed, Nov 14, 2012 at 12:29 PM, MICHAEL BUCHHOLTZ < wrote: The vast majority, 80%, are dead within 1 year; many within months. 20% live 2 years and small numbers longer. We will know better when pathology and genetic markers are back. That will help determine which meds might help. Ultimately the key will be if he does/does not repond to the treatments. I reviewed his scans and they are scary; he really has significant disease everywhere brain ,bone ,liver and lung. Michael On Wed, Nov 14, 2012 at 1:09 AM, Jeffrey Epstein wrote: Range of time.? On Tuesday, November 13, 2012, MICHAEL BUCHHOLTZ wrote: Brief update. Yesterday Warren was admitted to a local hospital and have a full work up done He was seen by radiation oncology; medical oncology and a biopsy of metastatic cancer to his thoracic spine was EFTA_R1_00464669 EFTA01977947  obtained. Preliminary results should be back by Thurs, with some special genetic testing back later next week. The MRI of his brain showed numerous metastatic deposits; more than 17 different tumors. I don't know if even Warren knows that number; I got this from my telephone discussion with the Radiation oncologist. He will start whole brain radiation therapy on Thurs; it is usually given every day (except weekends) for 2 weeks. After that he will start the systemic therapy. probably chemo; depending on the specific pathology and genetic evaluation. Terry has provided 2 names of outstanding MD's at University of Texas southwestern where we will go for an opinion to see if they have something unique/investigational to offer. Once he has the date for the opinion I will arrange to go down there so I will go with him to the appointment and then we can strategize a plan all together. Warren appears relatively realistic; he told Terry he is a dead man walking. He is incurable but it is possible he can get some type of response to treatment that can buy him quality time. He is willing to take an aggressive stance if appropriate and that is the right attitude to have. I have privately spoken with Linda and she is fully aware of the critical nature of his illness as well. They both appear to be dealing with this as well as we could hope for. I'll keep you informed as things progress. Warrens friends are an essential source of support and strength for both him and Linda right now. On Mon, Nov 12, 2012 at 9:49 AM, Jeffrey Epstein wrote: Thanks On Monday, November 12, 2012, MICHAEL BUCHHOLTZ wrote: I ve spoken w him twice this morning and insisted he be admitted to the hospital. It is clear to me that he is in shock and not thinking that clearly. He is in a state of denial. He told me how disruptive this all is; how he had to cancel all his patients today and didn't want to be in the hospital. I insisted and apparently he called his primary doctor who arranged for a consultation right now. They will call me from the doctors office III keep you informed. Also have spoken w your brother and Terry in San Diego this morning and obviously everyone is quite sad On Mon, Nov 12, 2012 at 7:54 AM, Jeffrey Epstein wrote: thanks, I would appreciate it if you kept me up, and of course, if needed trial experimental.ss . doesn't sound very good . EFTA_R1_00464670 EFTA01977948 On Mon Nov 12 2012 at 8:47 AM, MICHAEL BUCHHOLTZ < > wrote: The is a list of different possible cancers he might have and that is the first question to answer. I presume it is lung ( adenocarcinoma) but it could (less likely) even be a highly treatable testiular/germ cell tumor. It could be a melanoma. The difference is vital in terms of treatment and prognosis. Also some lung cancers In "non-smokers" can be more treatable with remissions lasting years. As of today the most upsetting fact is that it is so extensive ; lung ,brain, liver and bone. How long? Without having details weeks to months. But with luck Maybe much better; depending on the specific type and other specific biological characteristics of HIS cancer. Not many people win the lottery but some do. Right now I very sad and struggling to be hopeful On Sun, Nov 11, 2012 at 10:57 PM, Jeffrey Epstein wrote: how long? On Sun, Nov 11, 2012 at 10:15 PM, MICHAEL BUCHHOLTZ < wrote: Right now nothing. I asked him to send me actual copies of all his scans and labs. I ordered some medicines for him . The next step is to get an adequate "tissue " biopsy so we know exactly what we are dealing with. I will talk to his MDs down there and help coordinate the workup in a timely fashion and then we can strategize a therapeutic plan. I probably will fly down there once we have some more information . I have both his and Linda's contact information and III check in daily. They know they can can me 24/7. "IF" he is a candidate for some unique / " investigational" treatment we can then look to you to help if he doers not have easy accesss to it. Its very serious and very upsetting for all involved. Stay in touch Michael On Sun, Nov 11, 2012 at 7:54 PM, Jeffrey Epstein wrote: just got warrrens email . any thing i can do? *********************************************************** The information contained in this communication is confidential, may be attorney-client privileged, may EFTA_R1_00464671 EFTA01977949 constitute inside information, and is intended only for the use of the addressee. It is the property of Jeffrey Epstein Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to jeevacation(&gmail.com, and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved *********************************************************** The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of Jeffrey Epstein Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to jeevacationrci:gmail.com, and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved *********************************************************** The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of Jeffrey Epstein Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to jeevacation@gmail.com, and EFTA_R1_00464672 EFTA01977950 destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved *********************************************************** The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of Jeffrey Epstein Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to jeevacatiorKg)amai l .com, and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved *********************************************************** The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of Jeffrey Epstein Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to jeevacation@gmail.com, and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved *********************************************************** The information contained in this communication is confidential, may be attorney-client privileged, may EFTA_R1_00464673 EFTA01977951 constitute inside information, and is intended only for the use of the addressee. It is the property of Jeffrey Epstein Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to jeevacationki)grnail .corn, and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of Jeffrey Epstein Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by c-mail to iceNacation(iiumail.coni, and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved EFTA_R1_00464674 EFTA01977952