EFTA02667148.pdf

From: jeffrey E. <jeevacation@gmail.com> Sent: Wednesday, December 7, 2016 5:53 PM To: Donald Rubin Subject: Re: Placebo effects, EB, etc. query, why are so many distributions in natur= so consistant and accurate. doesnt it give you pause. = like centrigal force. not a true force but one we sens=. many distributions could be describeds as pseudo forces pus=ing the tails toward the mean. . . could gravity be one of t=ese pseudo type forces pushing things towards a distribution.?? *=A0 not as silly a question as it first might appear to be . :) =div class="gmail_extra"> On Wed, Dec 7, 20=6 at 1:47 PM, Donald Rubin t<mailtc > wrote: Think so.=C24> Where will you be? On Dec 7, 2016, at 12:25 PM, jeffrey E. <jeevacation@gmail.comqa» wrote: ar you around on the weekend in cambridg=.? On Wed, Dec 7, 2016 at 1:10 PM, Donald Rubin wrote: OK. I'll get back to you after I make contact with=Adriaan again, and my plans settle a bit. On Dec 7, 2016, at 10:38 AM, jef=rey E. <jeev=cation@gmail.com <mailto:jeevacation@gmail.com» wrote: three w=y skype for 3. and yes 1 face to face On Wed, Dec 7, 2016 at 11:37 AM, Donal= Rubin ail wrote: Different ways to follow up. 1. The next time that we're in the sam= town, we could talk about the statistical ideas underlying ways to disent=ngle placebo effects from biological effects of drugs and why that*=99s important for FDA approvals and for prescripts in the docs office 4>=804› different answers, I think. 2. I can =end some recent things on the topic of placebo response, which are still n=t that wonderfully written. EFTA_R1_01918781 EFTA02667148  3. If intereste= in exploring investing in EB, I can put you in touch with Adriaan, who Ikes in Amsterdam. Are any of these appealing?4>=A0 I prefer 1to 2. I think a face to face version of 3 could be arr=nged either here or there. Let me know. On Dec 7, 2016, at 9:35 AM, jeffr=y E. <jeevac=tion@gmail.com <mailto:jeevacation@gmail.com> wrote: I'm always interested in unique idea On Wed, Dec 7, 2016 at 10:12 AM Donald Rubin wr=te: Hello Jef=rey, I'm gl=d that Martin has put us in touch for a couple of reasons. First, I =hink we have some mutual interests concerning the complications of doing e=periments with humans, rather than plants or animals or tires. One c=mplication is noncompliance with the assigned treatment, which we briefly =iscussed at the dinner, but the more interesting one is the placebo effect= which can be gigantic, for example in "viagra" type studi=s, which we didn't get around to discussing except indirectly in t=e context of the Emotional Brain (EB) female viagra issue. More generally, this is rela=ed to FDA standards for approving drugs. A slight aside: in January=l'm one of three people getting honorary degrees from the Medical =acuity of the University of Uppsala in Sweden, where one of the others is =obert Califf, the current Commissioner of the FDA (the other is Marcia McN=tt, the current President of the National Academy of Sciences), so I shoul= get the chance to bend his ear at various meals (a former commissioner =E2401, under Bush II — was a partial PhD student of mine when he=was getting his MD at Harvard and his PhD in Econ at MIT, and remains a go=d friend: Mark McClellen, who is interested in this stuff and remains quit= influential in DC, I think). But the reason for rambling about the FDA and placebo eff=cts is the following. This morning I just had an exchange of emails =ith the CEO of EB, whom I've known and worked with for about three=years, Adriaan Tuiten. He wrote that FDA has agreed with EB'= proposal for more trials, and the EB board of directors just approved the=issuance of about 12 million Euros in stock to pay for these trials. =Adriaan thinks that they may have enough connections now, but would you be=interested in participating? I already have some stock, which I earn=d though consulting. I think EB is interesting but still needs more=wisdom when it comes to their statistics (I've been to FDA with th=m two or three times, and I think they still need help with some of their =deas e.g., using SNPs). If interested in tossing some money their wa=, let me know. In a=y case, I very much enjoyed our last conversations, and I look forward to =eeing you again, either in Cambridge or in NYC, which I'll probabl= get to in the next couple of weeks. Best wishes, Don .=br class="m_6900164931154966066m_-6698346136610420412m_- 1196805788815373=82gmail_msg"> 2 EFTA_R1_01918782 EFTA02667149  Donald B. Rubin John L. Loeb P=ofessor of Statistics <=1" On Dec 2, 2016, at 9:41 AM, jeffrey E. < great On Fri, Dec 2, 2016 at 9:=0 AM, Donald Rubi e: Great, thanks Martin= Sometime when I get to NYC, which I often do to visit Columbia conn=ctions, I'd like to be in touch, and give Jeffery more lectures in=statistics — I think he has some potential! <=r class="m_6900164931154966066m_-6698346136610420412m_- 11968057888153736=2gmail_msg"> Also, Martin, should we try to touch base on Monday?=C24› The rest of the week is pretty much shot for me with visitors. Best, Don 3 EFTA_R1_01918783 EFTA02667150  > On Dec 2, =016, at 9:32 AM Nowak Martin A <mai > wrote:=br class="m 1196805788815373=82gmail_msg"> &=t; Don , Jeffrey > I wou=d like to put you in direct email contact. > also cc Lesley. >m 40=A0 please note The information contained in this communication is confid=ntial, may be attorney-client privileged, may 4 EFTA_R1_01918784 EFTA02667151  constitute insi=e information, and is intended only for the use of the addres=ee. It is the property of JEE Unauthorized use, =isclosure or copying of this communication or any part thereo= is strictly prohibited and may be unlawful. If you have rece=ved this communication in error, please notify us immediately=by return e-mail or by e-mail to jeevacation@gmail.com <mailto:jeevacatio=@gmail.com> , and destroy this communication and all copies thereof, i=cluding all attachments. copyright -all rights reserved <=div> =C24, please note The information containe= in this communication is confidential, may be attorney-client privileg=d, may constitute inside information, and is intended only for the u=e of the addressee. It is the property of JEE Unauthorized use, disc=osure or copying of this communication or any part thereof is strictly =rohibited and may be unlawful. If you have received this communicati=n in error, please notify us immediately by return e-mail or by e-mail =o jeevacation@g=ail.com <mailto:jeevacation@gmail.com> , and destroy this communication and all copies thereof, =ncluding all attachments. copyright -all rights reserved </=iv> 40=A0 please note The information contained in this=communication is 5 EFTA_R1_01918785 EFTA02667152  confidential, may be attorney-client privileged, mayconstitute inside information, and is intended only for the use of the=addressee. It is the property of JEE Unauthorized use, disclosure or=copying of this communication or any part thereof is strictly prohibite= and may be unlawful. If you have received this communication in err=r, please notify us immediately by return e-mail or by e-mail to jeevacation@gmail.com<=a>, and destroy this communication and all copies thereof, including=all attachments. copyright -all rights reserved p=ease note The information contained in this communication is co=fidential, may be attorney-client privileged, may constitute inside inf=rmation, and is intended only for the use of the addressee. It is the p=operty of JEE Unauthorized use, disclosure or copying of this com=unication or any part thereof is strictly prohibited and may be unlawfu=. If you have received this communication in error, please notify us im=ediately by return e-mail or by e-mail to jeevacation@gmail.com <mailto:jeevacation=gmail.com> , and destroy thi= communication and all copies thereof, including all attachments. copyr=ght -all rights reserved 6 EFTA_R1_01918786 EFTA02667153